abstract：:The IL-15 triggering effect of gliadin is not exclusive to coeliac disease (CD) patients, whereas the secondary response is CD specific. We have studied the expression of the IL-15 receptor, and the IL-15 response upon stimulation, in non-CD and CD patients, and the possible existence of a lower immunological threshol...

journal_title：Clinical and experimental immunology

authors： Bernardo D,Garrote JA,Allegretti Y,León A,Gómez E,Bermejo-Martin JF,Calvo C,Riestra S,Fernández-Salazar L,Blanco-Quirós A,Chirdo F,Arranz E

更新日期：2008-10-01 00:00:00

abstract：:Human thymic stromal lymphopoietin (TSLP) promotes CD4(+) T-cell proliferation both directly and indirectly through dendritic cell (DC) activation. Although human TSLP-activated DCs induce CD8(+) T-cell proliferation, it is not clear whether TSLP acts directly on CD8(+) T cells. In this study, we show that human CD8(+...

journal_title：Clinical and experimental immunology

authors： Akamatsu T,Watanabe N,Kido M,Saga K,Tanaka J,Kuzushima K,Nishio A,Chiba T

更新日期：2008-10-01 00:00:00

abstract：:Patients with common variable immunodeficiency disorders are monitored for liver function test abnormalities. A proportion of patients develop deranged liver function and some also develop hepatomegaly. We investigated the prevalence of abnormalities and types of liver disease, aiming to identify those at risk and det...

journal_title：Clinical and experimental immunology

authors： Ward C,Lucas M,Piris J,Collier J,Chapel H

更新日期：2008-09-01 00:00:00

abstract：:Allergic disorders are viewed generally as organ diseases and thus referred to organ specialists, such as the ear, nose and throat specialist for rhinitis, the pulmonologist for asthma, the dermatologist for dermatitis, and so on. Indeed, the systemic nature of allergy is made evident by the fact that the same individ...

journal_title：Clinical and experimental immunology

authors： Pucci S,Incorvaia C

更新日期：2008-09-01 00:00:00

abstract：:Although the role of the T cell-mediated autoimmune reaction in type 1 diabetes (T1D) is conclusive, studies including data from human circulating CD4(+) and CD8(+) lymphocytes subsets during the disease onset and posterior development are scarce. Further, chemokines and chemokine receptors are key players in the migr...

journal_title：Clinical and experimental immunology

authors： Hedman M,Faresjö M,Axelsson S,Ludvigsson J,Casas R

更新日期：2008-09-01 00:00:00

abstract：:Enterohaemorrhagic Escherichia coli (EHEC) O157:H7 infections are considered a public health problem in both developed and developing countries because of their increasing incidence and the severity of clinical presentation. Approximately 10% of infected patients develop complications such as haemolytic uraemic syndro...

journal_title：Clinical and experimental immunology

authors： Brando RJ,Miliwebsky E,Bentancor L,Deza N,Baschkier A,Ramos MV,Fernández GC,Meiss R,Rivas M,Palermo MS

更新日期：2008-08-01 00:00:00

abstract：:Recent advances in immunological and genetic research in coeliac disease provide new and complementary insights into the immune response driving this chronic intestinal inflammatory disorder. Both approaches confirm the central importance of T cell-mediated immune responses to disease pathogenesis and have further beg...

journal_title：Clinical and experimental immunology

authors： Dubois PC,van Heel DA

更新日期：2008-08-01 00:00:00

abstract：:More than 11 genetic causes of severe combined immunodeficiency (SCID) have been identified, affecting development and/or function of T lymphocytes, and sometimes B lymphocytes and natural killer (NK) cells. Deletion of 22q11.2 is associated with immunodeficiency, although less than 1% of cases are associated with T-B...

journal_title：Clinical and experimental immunology

authors： Gennery AR,Slatter MA,Rice J,Hoefsloot LH,Barge D,McLean-Tooke A,Montgomery T,Goodship JA,Burt AD,Flood TJ,Abinun M,Cant AJ,Johnson D

更新日期：2008-07-01 00:00:00

abstract：:Cellular immunity with interferon gamma production could have a role in protection from hepatitis C virus (HCV). Interleukin (IL)-12 is a key cytokine in promoting such anti-viral T helper 1 (Th1) responses. We hypothesized that a genetic background able to promote cellular responses may be associated with apparent pr...

journal_title：Clinical and experimental immunology

authors： Hegazy D,Thurairajah P,Metzner M,Houldsworth A,Shaw S,Kaminski E,Demaine AG,Cramp ME

更新日期：2008-06-01 00:00:00

abstract：:Cytotoxic T lymphocytes (CTL) and natural killer (NK) cells have a key role in host defence against infectious pathogens, but their response to bacteria is not well characterized. Non-typeable Haemophilus influenzae is a major cause of respiratory tract infection including otitis media, sinusitis, tonsillitis and chro...

journal_title：Clinical and experimental immunology

authors： King PT,Ngui J,Farmer MW,Hutchinson P,Holmes PW,Holdsworth SR

更新日期：2008-06-01 00:00:00

abstract：:Regulatory T cells (T(regs)) may inhibit immunity against cancer. Induction and expansion of T(regs) in the immunosuppressive microenvironment created by a growing tumour appear to be one of the mechanisms by which it can evade host defence. We studied the impact of CD25+ T(regs) in a B cell lymphoma model in which Ra...

journal_title：Clinical and experimental immunology

authors： Heier I,Hofgaard PO,Brandtzaeg P,Jahnsen FL,Karlsson M

更新日期：2008-05-01 00:00:00

abstract：:Dendritic cells (DC) are specialized in the presentation of antigens and the initiation of specific immune responses. They have been involved recently in supporting innate immunity by interacting with various innate lymphocytes, such as natural killer (NK), NK T or T cell receptor (TCR)-gammadelta cells. The functiona...

journal_title：Clinical and experimental immunology

authors： Reschner A,Hubert P,Delvenne P,Boniver J,Jacobs N

更新日期：2008-05-01 00:00:00

abstract：:During 25 years of research since HIV-1 was first identified in Paris, there have been great advances in our understanding of the virus and of the immune system. Practical advances include the early development of diagnostic tests of infection that made blood donation safe, and since 1996, combination anti-retroviral ...

journal_title：Clinical and experimental immunology

authors： Weiss RA

更新日期：2008-05-01 00:00:00

abstract：:In Helicobacter pylori gastritis gastric epithelium plays a central role in the innate immunity to H. pylori. However, epithelial receptors interacting with H. pylori have been poorly characterized so far. Recently a new triggering receptor expressed on myeloid cells-1 (TREM-1) has been identified on human neutrophils...

journal_title：Clinical and experimental immunology

authors： Schmausser B,Endrich S,Beier D,Moran AP,Burek CJ,Rosenwald A,Rieckmann P,Müller-Hermelink HK,Eck M

更新日期：2008-04-01 00:00:00

abstract：:Clinical investigations of recombinant human acid alpha-glucosidase for the treatment of Pompe disease often reveal the appearance of therapy-specific antibodies. These antibodies could potentially interfere with recombinant human acid alpha-glucosidase efficacy and induce immunological consequences. Several immunosup...

journal_title：Clinical and experimental immunology

authors： Joseph A,Munroe K,Housman M,Garman R,Richards S

更新日期：2008-04-01 00:00:00

abstract：:Reduced B cell numbers and a mutation in Btk are considered sufficient to make the diagnosis of X-linked agammaglobulinaemia. In the process of conducting family studies, we identified a 58-year-old healthy man with an amino acid substitution, Y418H, in the adenosine-5'-triphosphate binding site of Btk. Immunofluoresc...

journal_title：Clinical and experimental immunology

authors： Conley ME,Farmer DM,Dobbs AK,Howard V,Aiba Y,Shurtleff SA,Kurosaki T

更新日期：2008-04-01 00:00:00

abstract：:In pulmonary sarcoidosis, the typical T helper 1-mediated immune response in the lungs has been proposed to be co-ordinated by regulatory T cells; however, their exact role needs to be clarified. We used real-time polymerase chain reaction to study genes involved in regulatory T cell functions in CD4+ T cells isolated...

journal_title：Clinical and experimental immunology

authors： Idali F,Wahlström J,Müller-Suur C,Eklund A,Grunewald J

更新日期：2008-04-01 00:00:00

abstract：:CD4+ lymphocytes are a primary target of the human immunodeficiency virus (HIV), and CD4 counts are one of the factors used to measure disease progression in HIV-positive individuals. CD4 counts vary in uninfected individuals and across populations due to a variety of demographic, environmental, immunological and gene...

journal_title：Clinical and experimental immunology

authors： Mair C,Hawes SE,Agne HD,Sow PS,N'doye I,Manhart LE,Fu PL,Gottlieb GS,Kiviat NB

更新日期：2008-03-01 00:00:00

abstract：:Neurotrophins nerve growth factor (NGF), brain-derived growth factor (BDNF), neurotrophin-3 (NT-3) and neurotrophin-4 (NT-4) and their high-affinity tyrosine protein kinase receptor (Trk) family, TrkA, TrkB, TrkC, and low-affinity p75(NTR) receptor, are key molecules implicated in the development of the central nervou...

journal_title：Clinical and experimental immunology

authors： Samah B,Porcheray F,Gras G

更新日期：2008-03-01 00:00:00

abstract：:The present study aimed to investigate BeWo trophoblast cell susceptibility to Toxoplasma gondii infection under stimulation with anti-inflammatory cytokines in comparison with HeLa cells. Both cell types were submitted to different treatments with recombinant cytokines [interleukin (IL)-10 and transforming growth fac...

journal_title：Clinical and experimental immunology

authors： Barbosa BF,Silva DA,Costa IN,Mineo JR,Ferro EA

更新日期：2008-03-01 00:00:00

abstract：:The diagnosis of neonatal sepsis is difficult, resulting in unnecessary treatment to minimize morbidity and mortality. We hypothesized that exposure to antenatal risk factors for sepsis alters the perinatal neutrophil phenotype. The study setting was a tertiary referral university-affiliated maternity and neonatal hos...

journal_title：Clinical and experimental immunology

authors： Molloy EJ,O'Neill AJ,Grantham-Sloan JJ,Webb DW,Watson RW

更新日期：2008-02-01 00:00:00

abstract：:Regulatory T cells seem to play a central role in maintaining immune tolerance in the gut mucosa. Previously we have shown that interleukin (IL)-10 is produced at high levels in the inflamed colonic tissue of ulcerative colitis (UC) patients. The cellular source was CD4+ T cells, suggesting local activation of regulat...

journal_title：Clinical and experimental immunology

authors： Sitohy B,Hammarström S,Danielsson A,Hammarström ML

更新日期：2008-02-01 00:00:00

abstract：:Adoptive immunotherapy with in vitro expanded antigen-specific cytotoxic T lymphocytes (CTLs) may be an effective approach to prevent, or even treat, Aspergillus (Asp) infections. Such lines can be generated using monocyte-derived dendritic cells (DC) as antigen-presenting cells (APC) but requires a relatively high vo...

journal_title：Clinical and experimental immunology

authors： Zhu F,Ramadan G,Davies B,Margolis DA,Keever-Taylor CA

更新日期：2008-02-01 00:00:00

abstract：:Superantigens (SAgs) are potent stimulators of T cells bearing specific Vbeta T cell receptors (TCR) and may play a role in the pathogenesis of Kawasaki syndrome (KS), although despite 15 years of intense study this area remains controversial. Because SAgs can cause Vbeta restricted T cell activation in the absence of...

journal_title：Clinical and experimental immunology

authors： Brogan PA,Shah V,Clarke LA,Dillon MJ,Klein N

更新日期：2008-02-01 00:00:00

abstract：:Factor H is an abundant plasma glycoprotein that plays a critical role in the regulation of the complement system in plasma and in the protection of host cells and tissues from damage by complement activation. Several recent studies have described the association of genetic variations of the complement factor H gene (...

journal_title：Clinical and experimental immunology

authors： de Córdoba SR,de Jorge EG

更新日期：2008-01-01 00:00:00

abstract：:Environmental factors such as diet are known to play important roles in inflammatory bowel disease (IBD). Epidemiological studies have indicated that a high-fat diet is a risk factor for IBD. In addition, the balance between effector T cells (T(eff)) and regulatory T cells (T(reg)) contributes to the pathogenesis of m...

journal_title：Clinical and experimental immunology

authors： Ma X,Torbenson M,Hamad AR,Soloski MJ,Li Z

更新日期：2008-01-01 00:00:00

abstract：:Recently we reported that monocyte phagocytosis and chemotaxis are impaired in X-linked agammaglobulinaemia (XLA) and common variable immunodeficiency (CVI) patients. Few data exist on the in vivo expression of receptors for the constant region of immunoglobulin (IgG) (Fc gammaR) and complement receptors (CR) in these...

journal_title：Clinical and experimental immunology

authors： Amoras AL,da Silva MT,Zollner RL,Kanegane H,Miyawaki T,Vilela MM

更新日期：2007-12-01 00:00:00

abstract：:The C77G polymorphism in exon A of the human CD45 gene occurs with low frequency in healthy individuals. An enhanced frequency of C77G individuals has been reported in cohorts of patients suffering from multiple sclerosis, systemic sclerosis, autoimmune hepatitis, hepatitis C and human immunodeficiency virus (HIV)-1. ...

journal_title：Clinical and experimental immunology

authors： Windhagen A,Sönmez D,Hornig-Do HT,Kalinowsky A,Schwinzer R

更新日期：2007-12-01 00:00:00

abstract：:Immune repopulation, despite virological failure, often occurs in children under highly active anti-retroviral therapy (HAART). The aim of this study was to analyse the characteristics of immune repopulation and activation in children with and without virological response to HAART. Fourteen human immunodeficiency viru...

journal_title：Clinical and experimental immunology

authors： Anselmi A,Vendrame D,Rampon O,Giaquinto C,Zanchetta M,De Rossi A

更新日期：2007-12-01 00:00:00

abstract：:Post-traumatic splenectomy is associated with increased postoperative morbidity and mortality and long-term impairment of humoral and cellular immunity. Alternatives to surgery have been developed to minimize or avoid the immediate and/or long-term complications of splenectomy. Herein we investigated the long-term eff...

journal_title：Clinical and experimental immunology

authors： Theodorou GL,Mouzaki A,Tsiftsis D,Apostolopoulou A,Mougiou A,Theodori E,Vagianos C,Karakantza M

更新日期：2007-12-01 00:00:00

abstract：:We investigated whether deficiency of mannose-binding lectin (MBL), a component of innate immunity, is associated with neonatal pneumonia and sepsis during the first 72 h, i.e. early onset, and during the first month after birth. In 88 neonatal intensive care patients (71 premature), MBL2 genotype and MBL plasma level...

journal_title：Clinical and experimental immunology

authors： Frakking FN,Brouwer N,van Eijkelenburg NK,Merkus MP,Kuijpers TW,Offringa M,Dolman KM

更新日期：2007-11-01 00:00:00

abstract：:In vitro studies have contributed substantially to the understanding of immunopathology of respiratory syncytial virus (RSV)-mediated disease. In the present study we compared the effect of RSV-infected dendritic cells on the time-course of the primary and memory/effector T cell response in vitro. Cultures with uninfe...

journal_title：Clinical and experimental immunology

authors： Rothoeft T,Fischer K,Zawatzki S,Schulz V,Schauer U,Körner Rettberg C

更新日期：2007-11-01 00:00:00

abstract：:L-ficolin (also called ficolin-2, P35 or hucolin) is a soluble pattern recognition molecule of suspected importance in anti-microbial immunity. It activates the lectin pathway of complement and acts as an opsonin. l-ficolin, encoded by the FCN2 gene, recognizes microbial polysaccharides and glycoconjugates rich in Glc...

journal_title：Clinical and experimental immunology

authors： Cedzynski M,Nuytinck L,Atkinson AP,St Swierzko A,Zeman K,Szemraj J,Szala A,Turner ML,Kilpatrick DC

更新日期：2007-10-01 00:00:00

abstract：:The role of T cells in the pathophysiology of chronic obstructive pulmonary disease (COPD) is not yet certain, although varying reports have shown increases in T helper 1 (Th1) and/or Th2 cytokines in peripheral blood and bronchoalveolar lavage (BAL). No studies have examined cytokine production by intraepithelial T c...

journal_title：Clinical and experimental immunology

authors： Hodge G,Nairn J,Holmes M,Reynolds PN,Hodge S

更新日期：2007-10-01 00:00:00

abstract：:Lyme borreliosis is a complex infection, where some individuals develop so-called 'chronic borreliosis'. The pathogenetic mechanisms are unknown, but the type of immune response is probably important for healing. A strong T helper cell type 1 (Th1)-like response has been suggested as crucial for eradication of Borreli...

journal_title：Clinical and experimental immunology

authors： Ekerfelt C,Andersson M,Olausson A,Bergström S,Hultman P

更新日期：2007-10-01 00:00:00

abstract：:In this second review on chemokines, we focus on the polymorphisms and alternative splicings and on their consequences in disease. Because chemokines are key mediators in the pathogenesis of inflammatory, autoimmune, vascular and neoplastic disorders, a large number of studies attempting to relate particular polymorph...

journal_title：Clinical and experimental immunology

authors： Colobran R,Pujol-Borrell R,Armengol MP,Juan M

更新日期：2007-10-01 00:00:00

abstract：:The aim of the present study was to elucidate the impact of liver transplantation (LTX) on myeloid dendritic cell (MDC) homeostasis. We observed a threefold reduction of circulating CD1c(+) MDC immediately after LTX (n = 16; P < 0.01), and normalization between 3 and 12 months after LTX. This decline was not due to re...

journal_title：Clinical and experimental immunology

authors： Bosma BM,Metselaar HJ,Tra WM,Mancham S,Kuipers EJ,Tilanus HW,Kwekkeboom J

更新日期：2007-09-01 00:00:00

abstract：:The guinea pig model of low-dose pulmonary tuberculosis has been used to study the pathogenesis of infection as well as the mechanisms of bacille Calmette-Guérin (BCG) vaccine-induced resistance. We investigated the function of lung cells from naive and BCG-vaccinated guinea pigs after enzymatic digestion of lung tiss...

journal_title：Clinical and experimental immunology

authors： Jeevan A,Majorov K,Sawant K,Cho H,McMurray DN

更新日期：2007-08-01 00:00:00

abstract：:Many patients surviving vasculitis are prone to accelerated atherosclerosis and often have enhanced levels of antibodies to oxidized low-density lipoprotein (oxLDL). To measure anti-oxLDL antibodies, oxidation of LDL is achieved with copper (Cu) or malondialdehyde (MDA). Because, in vivo, LDL may be oxidized with myel...

journal_title：Clinical and experimental immunology

authors： Slot MC,Theunissen R,van Paassen P,Damoiseaux JG,Tervaert JW,Limburg Nephrology Working Group.

更新日期：2007-08-01 00:00:00

abstract：:Peptide immunotherapy is being explored to modulate varied disease states; however, the mechanism of action remains poorly understood. In this study, we investigated the ability of a subcutaneous peptide immunization schedule to induce of CD4(+) CD25(+) T regulatory cells. DO11.10 T cell receptor (TCR) transgenic mice...

journal_title：Clinical and experimental immunology

authors： Dahlberg PE,Schartner JM,Timmel A,Seroogy CM

更新日期：2007-08-01 00:00:00